Brain scans of people with binge-eating disorder or bulimia reveal altered activity in areas linked to habit formation, suggesting potential new treatments for these conditions.
Researchers from Stanford University School of Medicine and the University of Pennsylvania found differences in brain structures related to dopamine signaling, which could help in understanding the brain mechanisms behind habit-driven eating behavior.
Researchers pinpointed two brain structures, the sensorimotor putamen and the associative caudate, as having a role in the formation of habits.
In order to locate these structures, they studied the links between the rat brain cortex and the striatum, utilizing high-resolution magnetic resonance imaging (MRI) data from a sample of 178 human subjects.
The researchers then studied the brains of 34 women with binge-eating disorder or bulimia nervosa and found altered activity in the sensorimotor putamen and the associative caudate.
Specifically, they found changes in the structure of the grey matter and in dopamine signaling, particularly in the sensorimotor putamen.
In individuals with eating disorders, the links between specific regions of the cortex and the habit-strengthening sensorimotor putamen were considerably more robust than in those without such disorders.
The degree of variation in brain scan results correlated directly with self-reported assessments of eating disorder severity.
Researchers from Stanford University School of Medicine and the University of Pennsylvania found differences in brain structures related to dopamine signaling, which could help in understanding the brain mechanisms behind habit-driven eating behavior.
Dopamine, a neurotransmitter released in response to reward, plays a significant role in habit formation.
The researchers found that the putamen in individuals with eating disorders had fewer dopamine receptors than healthy brains.
They suspect that increased dopamine release might reduce the sensitivity of these receptors and decrease their number.
These discoveries indicate that further investigation into novel therapies for binge-eating disorder and bulimia is warranted, given the historical resistance of these conditions to existing treatments.
Methods like deep-brain stimulation or transcranial magnetic stimulation might be employed to address the affected brain areas.
Moreover, the findings of this study suggest that upcoming interventions for a range of psychiatric disorders, not solely binge-eating disorder and bulimia, could focus on directly targeting brain circuitry.
The study revealed that the degree of alteration in the sensorimotor putamen’s connectivity correlated with the severity of disordered eating behavior.
This suggests that the formation of a structural neural circuit links habit learning and binge eating behavior in humans.
The authors conclude that future treatments involving the modulation of these circuit-based mechanisms could potentially treat habitual behaviors underlying the treatment-resistant nature of many psychiatric disorders, not limited to eating disorders.
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